RESEARCH SHOWS THAT OBESITY MAY INCREASE RISK OF CANCER
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A general overview of obesity and cancer
An increased level of fat deposition in the body affects the physical and mental health of an individual that gradually reduces life expectancy, which is termed as obesity. Obesity is one of the considerable factors for DALYs (Disability-adjusted life years), which means it increases premature death. A research study reported that approximately 2.3% of global DALYs are caused due to obesity, resulting in the death of 2.8 million people each year. [1] Whereas, cancer has a major impact on society all over the world. According to the American Cancer Society, 5,000,000 Americans in the United States die due to cancer. Abnormal and uncontrollable cell growth is the root cause of cancer or malignancy. Classification of cancer depends upon the type of cells that are initially affected. Almost 100 or more variety of cancerous growth are identified by medical science, most common are blood cancer, lymph cancer, breast cancer, prostate cancer, lung cancer, liver cancer, skin cancer, stomach cancer, pancreas cancer, colon cancer and so on. |
Cancer can develop in any part of the body when a tumor growth is spread to associated parts. Cell proliferation or limited apoptosis, abnormal base pairing in DNA or increased oxidative stress due to excessive production of free radicals are different pathophysiologies of cancer. The signs and symptoms depend upon the organ that is primarily affected. [2]
The correlation between obesity and cancer
There is a correlation between obesity and cancer incidence. Although obesity also increases the risk of other multiple diseases including cardiovascular diseases, stroke, diabetes, musculoskeletal disorders (especially osteoarthritis - a highly disabling degenerative disease of the joints), gallstones, non-alcoholic steatohepatitis, pulmonary hypertension, sleep apnea, etc. [3,4]
The correlation between obesity and cancer
There is a correlation between obesity and cancer incidence. Although obesity also increases the risk of other multiple diseases including cardiovascular diseases, stroke, diabetes, musculoskeletal disorders (especially osteoarthritis - a highly disabling degenerative disease of the joints), gallstones, non-alcoholic steatohepatitis, pulmonary hypertension, sleep apnea, etc. [3,4]
The mechanism behind this can be illustrated by following way:
Obesity increases the risk of insulin resistance and the combination of these biophysiological changes often elevates the production of leptin hormone. Higher leptin level has a direct impact on increasing hyperinsulinemia, promoting inflammation and inducing aromatase enzymes that raises estrogen production in postmenopausal women.
Research evidence demonstrates the positive association of higher leptin with cancer cell growth.
Another mechanism also supports the association of CVD with diabetes and cancer. The adipose tissue releases cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6).
These combined factors are responsible for promoting the inflammation, insulin resistance, and endothelial dysfunction which is linked with type 2 diabetes and coronary artery disease (CAD), as well as support cancer progression by boosting cell proliferation and reducing apoptosis. [5]
Is there any single natural entity to combat these two fatal conditions?
Depending upon their mechanism of action, there are currently two types of anti-obesity drugs available:
• One of these is orlistat, which reduces intestinal fat absorption through inhibition of pancreatic lipase.
• The other is sibutramine, which is an anorectic, or appetite suppressant.
Both these categories of drugs are having a range of side effects, including hypertension, headache, insomnia, dry mouth, and constipation. [3]
In the other hand, we are aware of several conventional anticancer therapies like chemotherapy, radiation therapy, and surgery, which have various side effects. Therefore, medical scientists are keen to discover potential anti-obese, as well as anticancer natural products which can increase patients' compliance, and save them from high-cost medications and potentially hazardous side effects associated with them.
Researchers found Nigella sativa or black cumin, the unique nature's product which are tiny black triangular shaped seeds, and possess immense potentials to combat both obesity and cancer.
Nigella sativa as anti-obesity agent
Hypercholesterolemia is frequently found in patients with obesity. [6] BMI gets increased more in the hypercholesterolemic individual and is associated with increased relative weight. The increased relative weight is also associated with a deleterious effect on blood lipids. [7]
N. sativa can able to perform the choleretic function. This can be achieved either by reducing the synthesis of cholesterol by hepatocytes or by inhibiting its fractional re-absorption from the gut. The active constituents present in N. sativa are linoleic acid, oleic acid, eicosadienoic acid, and dihomo linolenic acid, which are all unsaturated fatty acid and its phytosterols components, which have a hypocholesterimic effect and decrease cholesterol level.
The anti-oxidant property of black seed also provides preventive action against obesity and its related complication. As per the expert's recommendation, aerobic exercise with N. sativa supplementation helps to control cholesterol level [1] and obesity.
In addition, food craving is also reduced by the mild anorexic effect of the N. sativa, which further reduce belly fat. [8]
According to the BBC.com "
Being overweight or obese is a growing cause of cancer in the UK while cases caused by smoking are falling, according to a large study.
Cancer Research UK found more than a third of all cases of cancer were avoidable - some 135,000.
The charity also found that excess weight now caused 6.3% of all cancer cases - up from 5.5% in 2011 - while smoking as a cause had declined.
It said more action was needed to tackle the "health threat" of obesity.
Cancer Research UK found the country with the greatest proportion of preventable causes of cancer was Scotland with 41.5%, followed by Northern Ireland on 38%, Wales on 37.8%, and England on 37.3%."
Being overweight or obese is a growing cause of cancer in the UK while cases caused by smoking are falling, according to a large study.
Cancer Research UK found more than a third of all cases of cancer were avoidable - some 135,000.
The charity also found that excess weight now caused 6.3% of all cancer cases - up from 5.5% in 2011 - while smoking as a cause had declined.
It said more action was needed to tackle the "health threat" of obesity.
Cancer Research UK found the country with the greatest proportion of preventable causes of cancer was Scotland with 41.5%, followed by Northern Ireland on 38%, Wales on 37.8%, and England on 37.3%."
Nigella sativa as anticancer agent
N. sativa is one of the primary sources of thymoquinone, which has potent anti-oxidant, cytotoxic, anti-carcinogenic, anti-proliferative, pro-apoptotic, anti-mutagenic and anti-metastatic effect. [9] N. Sativa significantly decreases cell proliferation and alter morphological changes induced by carcinogenic progression.
Tumor initiation and progression is inhibited by N. sativa due to its anti-inflammatory effect, and immunity boosting property. The anticancer effect of N. sativa is achieved by cell shrinkage and membrane damage, in association with DNA damage and cell death. The anti-tumorigenesis and anticancer activity of N. sativa are also attributed through enhancing the natural killer (NK) cytotoxic activity against cancer cells and regulate iNOS, p53, and caspases signaling pathways. [10]
The anticancer activity of N. sativa is tested through several animal research and laboratory investigations, and the evidence showed positive result against multiple cancerous growths including blood cancer, breast cancer, colon cancer, pancreatic cancer, liver cancer, lung cancer, skin cancer, renal cancer, prostate cancer, cervical cancer etc. [9]
Direction
Dosing
The recommended dose for black seed is in between 250mg to 1g per day. You can choose both black seed oil or raw black seeds powder. However, I must emphasize that I know of no seed as powerful as Perfect Press Black Seed Oil. The dosing can be measured as:
One teaspoon of black seed oil = two and a half teaspoons of powdered black seeds [11]
Anti-obesity
Experts suggested that the best anti-obesity result can be achieved by mixing black seed preparation with cinnamon and honey. The combination can be taken half an hour before breakfast and two hours after dinner. A clinical trial report documented that 1.5 gm black seeds powder twice daily for three months provides great benefit against obesity. [12]
Anti-cancer
A mixture of one teaspoon of black seed oil and honey provide great cancer protective effect. Take this mixture at morning, just half an hour before breakfast. In the afternoon, take a mixture of one teaspoon of black seed oil, honey, and saffron infused oil to achieve the best result. [13]
Which Black Seed Oil Do I Recommend?
I cannot emphasize enough the need to have the best black seed oil in your system. The black seed oil I and many others like Sayer Ji from GreenmedInfo.com is Perfect Press Black Seed Oil. Sign up for autoship and you will get a reduced price of $42 and receive a free bottle of Ease Magnesium Oil, which I advocate for pain and strokes. What a bargain!! Buy Here
References
- Esmail Farzaneh, Farhad Rahmani Nia, Mohammad Mehrtash, Fatemeh Sadat Mirmoeini, Mohammad Jalilvand. The Effects of 8-week Nigella sativa Supplementation and Aerobic Training on Lipid Profile and VO2 max in Sedentary Overweight Females. Int J Prev Med. 2014 Feb; 5(2): 210–216. Online available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950745/
- Cancer: What you need to know. Medical News Today. Online available at http://www.medicalnewstoday.com/info/cancer-oncology/
- Hanaa H. Ahmed, Fateheya M. Metwally, Hend Rashad, Asmaa M. Zaazaa3, Shahira M. Ezzat4, Maha M. Salama. Moringa oleifera offers a Multi-Mechanistic Approach for Management of Obesity in Rats. Int. J. Pharm. Sci. Rev. Res., 29(2), November – December 2014; Article No. 19, Pages: 98-106. Online available at http://miracletrees.org/moringa-doc/antiobesity-activity-of-moringa-oleifera2.pdf
- Obesity and overweight. Fact sheet. Online available at http://www.who.int/mediacentre/factsheets/fs311/en/
- Karen Collins. The Cancer, Diabetes, and Heart Disease Link. Today's Dietitian. Online available at http://www.todaysdietitian.com/newarchives/030413p46.shtml
- TATU A. MIETTINEN. Cholesterol Production in Obesity. Online available at http://circ.ahajournals.org/content/44/5/842.full.pdf
- Tershakovec AM, Jawad AF, Stouffer NO, Elkasabany A, Srinivasan SR, Berenson GS. Persistent hypercholesterolemia is associated with the development of obesity among girls: the Bogalusa Heart Study. Am J Clin Nutr. 2002 Oct;76(4):730-5. Online available at http://www.ncbi.nlm.nih.gov/pubmed/12324284
- Le PM, Benhaddou-Andaloussi A, Elimadi A, Settaf A, Cherrah Y, Haddad PS. The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat. J Ethnopharmacol. 2004 Oct;94(2-3):251-9. Online available at https://www.ncbi.nlm.nih.gov/pubmed/15325727
- Md Asaduzzaman Khan, Han-chun Chen, Mousumi Tania, Dian-zheng Zhang. Anticancer Activities of Nigella Sativa (Black Cumin). Afr J Tradit Complement Altern Med. 2011; 8(5 Suppl): 226–232. Published online 2011 Jul 3. doi: 10.4314/ajtcam.v8i5S.10. Online available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252704/
- Amin F. Majdalawieh, Muneera W. Fayyad. Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive. J Ayurveda Integr Med. 2016 Jul-Sep; 7(3): 173–180. Published online 2016 Sep 17. doi: 10.1016/j.jaim.2016.07.004. Online available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052360/
- Black seed & honey – a natural cure. Cancer is gone! Online available at http://healthywithhoney.com/black-seed-honey-a-natural-cure-cancer-is-gone/
- Can You Loss Weight with Nigella Sativa. Online available at https://www.nigella--sativa.com/can-you-lose-weight-with-nigella-sativa.html
- Proper Dosages For Nigella Sativa. Online available at https://www.nigella--sativa.com/dosages.html